Michael H Ossipov Selected Research

Dynorphins (Dynorphin)

11/2010	Attenuation of persistent experimental pancreatitis pain by a bradykinin b2 receptor antagonist.
12/2008	Spinal dynorphin and bradykinin receptors maintain inflammatory hyperalgesia.
8/2007	Control of chronic pain by the ubiquitin proteasome system in the spinal cord.
5/2007	Spinal NK-1 receptor expressing neurons mediate opioid-induced hyperalgesia and antinociceptive tolerance via activation of descending pathways.
12/2006	Dynorphin A activates bradykinin receptors to maintain neuropathic pain.
6/2006	Descending facilitation from the rostral ventromedial medulla maintains visceral pain in rats with experimental pancreatitis.
3/2006	Opioid receptor-mediated hyperalgesia and antinociceptive tolerance induced by sustained opiate delivery.
1/2005	Underlying mechanisms of pronociceptive consequences of prolonged morphine exposure.
6/2004	Production of paradoxical sensory hypersensitivity by alpha 2-adrenoreceptor agonists.
6/2003	Induction of pain facilitation by sustained opioid exposure: relationship to opioid antinociceptive tolerance.

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Michael H Ossipov Research Topics

Disease

45	Pain (Aches) 06/2020 - 01/2002
26	Hypersensitivity (Allergy) 03/2014 - 06/2002
23	Hyperalgesia 07/2012 - 06/2004
18	Neuralgia (Stump Neuralgia) 01/2018 - 01/2002
13	Chronic Pain 01/2017 - 01/2005
12	Migraine Disorders (Migraine) 06/2020 - 02/2009
6	Inflammation (Inflammations) 11/2010 - 10/2008
4	Headache (Headaches) 08/2013 - 10/2008
3	Neoplasms (Cancer) 02/2019 - 01/2005
3	Secondary Headache Disorders 02/2011 - 03/2010
3	Pancreatitis 11/2010 - 06/2006
3	Peripheral Nerve Injuries 02/2010 - 06/2004
2	Postoperative Pain 01/2017 - 12/2012
2	Major Depressive Disorder (Major Depressive Disorders) 01/2017 - 03/2016
2	Crush Injuries 03/2014 - 04/2008
2	Nervous System Diseases (Neurological Disorders) 05/2013 - 08/2010
2	Visceral Pain 10/2010 - 10/2008
2	Vomiting 05/2009 - 01/2005
2	Nausea 05/2009 - 01/2005
1	Erythema 01/2018
1	Injection Site Reaction 01/2018
1	Pruritus (Itching) 01/2018
1	Mental Disorders (Mental Disorder) 01/2017
1	Attention Deficit Disorder with Hyperactivity (Attention Deficit Hyperactivity Disorder) 01/2017
1	Neurogenic Inflammation 01/2017
1	Low Back Pain (Lumbago) 01/2017
1	Osteoarthritis 01/2017
1	Nociceptive Pain 01/2017

Drug/Important Bio-Agent (IBA)

23	Opioid Analgesics (Opioids)IBA 01/2018 - 08/2002
13	Morphine (MS Contin)FDA LinkGeneric 01/2017 - 08/2002
13	Dynorphins (Dynorphin)IBA 11/2010 - 06/2002
11	Analgesics (Analgesic Drugs)IBA 01/2017 - 06/2003
10	Opiate AlkaloidsIBA 01/2017 - 01/2005
10	Lidocaine (Xylocaine)FDA LinkGeneric 08/2013 - 06/2002
7	Pharmaceutical PreparationsIBA 02/2019 - 06/2004
6	Tryptamines (Triptans)IBA 06/2020 - 10/2008
5	Calcitonin Gene-Related PeptideIBA 06/2020 - 02/2009
4	Ondansetron (Zofran)FDA LinkGeneric 08/2013 - 05/2007
4	Cholecystokinin B ReceptorIBA 08/2013 - 01/2005
4	Sumatriptan (Imigran)FDA LinkGeneric 08/2013 - 10/2008
4	Cholecystokinin Receptors (Cholecystokinin Receptor)IBA 06/2011 - 01/2005
3	Neurotransmitter Agents (Neurotransmitter)IBA 06/2020 - 12/2005
3	NeuropeptidesIBA 06/2020 - 01/2005
3	Serotonin (5 Hydroxytryptamine)IBA 06/2020 - 08/2013
3	Nerve Growth Factor (NGF)IBA 01/2017 - 06/2011
3	Duloxetine Hydrochloride (Cymbalta)FDA Link 01/2017 - 03/2014
3	Proteins (Proteins, Gene)FDA Link 09/2014 - 08/2007
3	Opioid Receptors (Opioid Receptor)IBA 06/2011 - 06/2004
3	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 06/2011 - 01/2005
3	dibutyldichlorotinIBA 11/2010 - 10/2008
3	Cholecystokinin (Pancreozymin)IBA 03/2009 - 01/2005
3	dermorphin-saporinIBA 03/2009 - 06/2002
2	lasmiditanIBA 06/2020 - 01/2020
2	Monoclonal AntibodiesIBA 01/2018 - 01/2017
2	Dopamine (Intropin)FDA LinkGeneric 08/2014 - 12/2012
2	6-chloro-2-(1-piperazinyl)pyrazine (CPP)IBA 08/2014 - 08/2013
2	Norepinephrine (Noradrenaline)FDA LinkGeneric 06/2014 - 03/2014
2	ElementsIBA 06/2014 - 06/2011
2	salicylhydroxamic acid (SHAM)IBA 03/2014 - 09/2003
2	Local AnestheticsIBA 12/2012 - 06/2004
2	Substance PIBA 07/2012 - 10/2010
2	Iodoacetic AcidIBA 04/2012 - 04/2011
2	LigandsIBA 06/2011 - 01/2005
2	Glial Cell Line-Derived Neurotrophic Factor (GDNF)IBA 06/2011 - 01/2005
2	Clonidine (ST 155)FDA LinkGeneric 04/2011 - 06/2004
2	Proteasome Endopeptidase Complex (Proteasome)IBA 07/2010 - 08/2007
2	Proteasome InhibitorsIBA 07/2010 - 08/2007
2	SaporinsIBA 03/2009 - 05/2007
2	mu Opioid Receptors (mu Opioid Receptor)IBA 03/2009 - 06/2002
2	BradykininIBA 12/2008 - 12/2006
2	Bradykinin Receptors (Bradykinin Receptor)IBA 12/2008 - 12/2006
2	Neurokinin-1 Receptors (Neurokinin 1 Receptor)IBA 05/2007 - 08/2005
2	L-Type Calcium Channels (Dihydropyridine Receptor)IBA 12/2005 - 09/2003
2	Ion Channels (Ion Channel)IBA 10/2005 - 06/2004
2	Sodium Channels (Sodium Channel)IBA 10/2005 - 01/2002
2	Dizocilpine Maleate (Dizocilpine)IBA 06/2004 - 11/2002
1	Serotonin Receptor Agonists (Serotonin Receptor Agonist)IBA 06/2020
1	Glutamic Acid (Glutamate)FDA Link 06/2020
1	Blood Proteins (Serum Proteins)IBA 06/2020
1	DNA (Deoxyribonucleic Acid)IBA 02/2019
1	galcanezumabIBA 01/2018
1	Ethanol (Ethyl Alcohol)IBA 01/2017
1	Cannabinoid Receptors (Cannabinoid Receptor)IBA 01/2017
1	CB2 Cannabinoid ReceptorIBA 01/2017
1	Cocaine (Cocaine HCl)IBA 01/2017
1	Atomoxetine Hydrochloride (Strattera)FDA LinkGeneric 01/2017
1	Nicotine FDA Link 01/2017
1	KetorolacIBA 08/2014
1	Biomarkers (Surrogate Marker)IBA 08/2014
1	Gabapentin (Neurontin)FDA LinkGeneric 08/2014
1	Naproxen (Naprosyn)FDA LinkGeneric 08/2014

Therapy/Procedure

21	Therapeutics 06/2020 - 06/2002
9	Ligation 01/2018 - 06/2002
4	Spinal Injections 04/2011 - 06/2004
3	Analgesia 01/2017 - 05/2009
1	Subcutaneous Injections 01/2018
1	Physical Therapy Modalities (Physical Therapy Technique) 01/2017
1	Orthopedic Procedures 01/2017
1	Hip Replacement Arthroplasty (Total Hip Replacement) 01/2017
1	Knee Replacement Arthroplasty (Total Knee Replacement) 01/2017